Why book a holiday in Rhine-Main Region?
The Rhine-Main region includes cities like Frankfurt am Main with its skyline, historic Wiesbaden, the Rheingau with its vineyards, Mainz, and the Taunus region.
Package Holidays Rhine-Main Region 2026
Experience an unforgettable holiday in Rhine-Main Region. We compare the best flight and hotel offers for you.
Rhine-Main Region Package Holiday Comparison
Popular Hotels in Rhine-Main Region
Here are the top-rated accommodations for your trip to Rhine-Main Region.
HOT DEAL
Flight + Hotel
Holiday Inn - the niu, Mood Mainz
Mainz, Germany
6 Nights, incl. Flight, Self Catering, Double Room
Total price p.p. from CHF 469.-
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HOT DEAL
Flight + Hotel
Holiday Inn Express & Suites Monheim am Rhein
Monheim am Rhein, Germany
6 Nights, incl. Flight, Breakfast, Double Room
Total price p.p. from CHF 454.-
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HOT DEAL
Flight + Hotel
Zleep Hotel Frankfurt Airport Kelsterbach
Kelsterbach, Germany
6 Nights, incl. Flight, Breakfast, Double Room
Total price p.p. from CHF 407.-
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HOT DEAL
Flight + Hotel
tinyTwice Hotel Wiesbaden
Wiesbaden, Germany
7 Nights, incl. Flight, Breakfast, Double Room
Total price p.p. from CHF 652.-
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HOT DEAL
Flight + Hotel
AC Hotel by Marriott Mainz
Mainz, Germany
6 Nights, incl. Flight, Self Catering, according to catalog
Total price p.p. from CHF 647.-
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HOT DEAL
Flight + Hotel
Best Western Premier Hotel Villa Stokkum
Hanau, Germany
6 Nights, incl. Flight, Self Catering, Double Room
Total price p.p. from CHF 678.-
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HOT DEAL
Flight + Hotel
Holiday Inn Express Darmstadt
Darmstadt, Germany
6 Nights, incl. Flight, Breakfast, Double Room
Total price p.p. from CHF 407.-
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HOT DEAL
Flight + Hotel
Radisson Blu Hotel Mannheim
Mannheim, Germany
6 Nights, incl. Flight, lt. Programm, Double Room
Total price p.p. from CHF 631.-
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HOT DEAL
Flight + Hotel
Mercure Hotel Mainz City Center
Mainz, Germany
6 Nights, incl. Flight, Self Catering, Double Room
Total price p.p. from CHF 599.-
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5-Star Luxury in Rhine-Main Region
Treat yourself to pure luxury in the most exclusive resorts of Rhine-Main Region.
PREMIUM
Flight + Hotel
Wald.Weit Rheingau Hotel & Retreat
Kiedrich, Germany
7 Nights, incl. Flight, Breakfast, Double Room
Total price p.p. from CHF 1'311.-
Luxury Details
PREMIUM
Flight + Hotel
Dorint Pallas Wiesbaden
Wiesbaden, Germany
5 Nights, incl. Flight, Breakfast, Double Room
Total price p.p. from CHF 713.-
Luxury Details
PREMIUM
Flight + Hotel
Steigenberger Icon Grandhotel & Spa Petersberg
Königswinter, Germany
6 Nights, incl. Flight, Self Catering, Double Room
Total price p.p. from CHF 795.-
Luxury Details
Popular Places in Rhine-Main Region
Aschaffenburg (ab CHF 613.-)Darmstadt (ab CHF 407.-)Eschborn (ab CHF 328.-)Hanau (ab CHF 678.-)Kaarst (ab CHF 477.-)Kelsterbach (ab CHF 399.-)Kiedrich (ab CHF 1'311.-)Königswinter (ab CHF 795.-)Mainz (ab CHF 418.-)Mannheim (ab CHF 426.-)Monheim am Rhein (ab CHF 454.-)Mörfelden-Walldorf (ab CHF 426.-)Offenbach am Main (ab CHF 534.-)Raunheim (ab CHF 402.-)Rüsselsheim am Main (ab CHF 308.-)Troisdorf (ab CHF 447.-)Wesel (ab CHF 938.-)Wiesbaden (ab CHF 425.-)
Questions about Package Holidays to Rhine-Main Region
When is the best time to travel to Rhine-Main Region?
This depends on your activities, but most travelers visit Rhine-Main Region during the main season.
How do I find cheap offers for Rhine-Main Region?
Use our comparison calculator to find daily updated offers for Rhine-Main Region. Flights and hotels are conveniently displayed in CHF.